Polyphenols (PPs) have the potential of combating Alzheimer’s disease (AD). The naturally occurring Polyphenols can reduce the societal burden of this debilitating neurodegenerative disorder.
Alzheimer’s Disease is a widely prevalent progressive neurodegenerative disorder marked by memory and cognitive decline
It remains poorly understood despite decades of dedicated research.
As a consequence of this, there is no therapeutics to completely cure the disease.
Ferroptosis, an iron-dependent form of programmed cell death, has emerged as a significant contributor to the development of AD.
Study by scientists of Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) presents naturally occurring polyphenols (PPs) as innovative and multimodal therapeutic agent with dual capabilities to ameliorate ferroptosis and AD.
JNCASR is an autonomous institute of the Department of Science and Technology (DST).
The study published in the journal Chemical Sciences which steers research toward ferroptosis inhibitors presents a new dimension for drug development. This discovery may inspire medicinal chemists to explore new and derivatives of natural compounds to enhance therapeutic efficacy against AD.